杰奎琳-K-巴顿 生物物理化学家

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Jacqueline K. Barton
Biophysical Chemist | Class of 1991
Title
Biophysical Chemist
Location
Pasadena, California
Age
39 at time of award
Area of Focus
Chemistry
Published July 1, 1991
ABOUT JACQUELINE'S WORK
Jacqueline Barton is a biophysical and inorganic chemist who studies the chemistry of gene expression.

Her research has focused on designing transition metal complexes that target and probe specific sites along DNA and RNA strands. Using chiral coordination complexes, matching their shapes, symmetries, and functionalities to sites along the strand, she has developed complexes that recognize nucleic acid sites with high specificity. These complexes have been useful in exploring principles in molecular recognition, as mimics for gene regulatory proteins, as photophysical and photochemical probes of nucleic acids, and in exploring reactions on nucleic acids such as electron transfer chemistry.

BIOGRAPHY
Barton is the Arthur and Marion Hanisch Memorial Professor of Chemistry at the California Institute of Technology. She taught previously at Columbia University (1983-89). She has published articles in such journals as Science and the Proceedings of the National Academy of Sciences USA.

Barton received an A.B. (1974) from Barnard College and a Ph.D. (1979) from Columbia University.

Last updated January 1, 2005



杰奎琳-K-巴顿
生物物理化学家 | 1991级
职称
生物物理化学家
工作地点
帕萨迪纳，加利福尼亚州
年龄
获奖时为39岁
重点领域
化学
发表于1991年7月1日
关于杰奎琳的工作
杰奎琳-巴顿是一位生物物理和无机化学家，研究基因表达的化学。

她的研究重点是设计过渡金属配合物，以DNA和RNA链上的特定部位为目标并进行探测。利用手性配位复合物，将其形状、对称性和功能与链上的位点相匹配，她已经开发出能高度识别核酸位点的复合物。这些复合物在探索分子识别原理方面很有用，可以作为基因调节蛋白的模拟物，作为核酸的光物理和光化学探针，以及探索核酸的反应，如电子转移化学。

个人简历
巴顿是加州理工学院化学系的亚瑟和马里恩-哈尼施纪念教授。她曾在哥伦比亚大学任教（1983-89）。她曾在《科学》和《美国国家科学院院刊》等杂志上发表文章。

巴顿获得了巴纳德学院的学士学位（1974）和哥伦比亚大学的博士学位（1979）。

最后更新于2005年1月1日