Carolyn Bertozzi 有机化学家

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Carolyn Bertozzi
Organic Chemist | Class of 1999
Title
Organic Chemist
Location
Albany, California
Age
33 at time of award
Area of Focus
Chemistry
Published July 1, 1999
ABOUT CAROLYN'S WORK
Carolyn Bertozzi is a chemist who has made important contributions to understanding how cells interact.

Using her knowledge of cell biology, she has developed a method for tricking cells into expressing non-natural sugars on their surface, which can be subsequently modified chemically to suit experimental design. This chemical remodeling technique provides a valuable tool for investigating and developing treatments for disease processes such as infection, inflammation, and cancer proliferation. Bertozzi designed a method by which cells can be caused to display modified sugar structures, which can then be "remodeled" chemically under non-toxic experimental conditions. She then uses these modified cells to test the relationships between the carbohydrate structure and its physical and biological properties. Her technical innovations find application in her laboratory, where she investigates such important scientific questions as how proteins fold, how cells communicate, and how cancer might be controlled.

BIOGRAPHY
Bertozzi is a professor in the departments of Chemistry and Molecular and Cell Biology at the University of California, Berkeley, an investigator at the Howard Hughes Medical Institute, and a research scientist in the Material Sciences Division of Lawrence Berkeley National Laboratory.

Bertozzi received an A.B. (1988) from Harvard University and a Ph.D. (1993) from the University of California, Berkeley.

Last updated January 1, 2005



Carolyn Bertozzi
有机化学家 | 1999级
职称
有机化学家
工作地点
奥尔巴尼，加利福尼亚
年龄
获奖时为33岁
重点领域
化学
发表于1999年7月1日
关于卡罗琳的工作
Carolyn Bertozzi是一位化学家，对了解细胞如何相互作用做出了重要贡献。

利用她在细胞生物学方面的知识，她开发了一种诱使细胞在其表面表达非天然糖的方法，随后可对其进行化学改造以适应实验设计。这种化学重塑技术为研究和开发治疗疾病过程（如感染、炎症和癌症增殖）提供了一个有价值的工具。Bertozzi设计了一种方法，可以使细胞显示出改良的糖结构，然后可以在无毒的实验条件下进行化学 "重塑"。然后，她利用这些改性细胞来测试碳水化合物结构与其物理和生物特性之间的关系。她的技术创新在她的实验室中得到了应用，在那里她研究了诸如蛋白质如何折叠、细胞如何沟通以及癌症如何被控制等重要的科学问题。

个人简历
伯托兹是加州大学伯克利分校化学系和分子与细胞生物学系的教授，霍华德-休斯医学研究所的调查员，以及劳伦斯伯克利国家实验室材料科学部的研究科学家。

伯托兹获得了哈佛大学的学士学位（1988年）和加利福尼亚大学伯克利分校的博士学位（1993年）。

最后更新于2005年1月1日